Mucosal Biology


Hot off the Press

From the University of Illinois News Bureau:

Photo of Rex Gaskins, Ann Benefiel, Eugene Greenberg, and Franck Carbonero
Photo by L. Brian Stauffer, University of Illinois News Bureau

Researchers map minority microbes in the colon

Researchers got a first look at microbes that inhabit the colonic mucosa. Pictured, from left, University of Illinois animal sciences and Institute for Genomic Biology professor Rex Gaskins, animal sciences visiting research specialist Ann Benefiel, Carle Foundation Hospital gastroenterologist Dr. Eugene Greenberg, and postdoctoral researcher Franck Carbonero.


Recent Publications

Kolossov VL, Leslie MT, Chatterjee A, Sheehan BM, Kenis PJ, Gaskins HR. Förster resonance energy transfer-based sensor targeting endoplasmic reticulum reveals highly oxidative environment. Exp Biol Med, 2012, 237(6): 652-62. Epub 2012 Jun 19.

Carbonero F, Benefiel AC, Gaskins HR. Contributions of the microbial hydrogen economy to colonic homeostasis. Nat Rev Gastroenterol Hepatol, 2012, 9 (9):504-18. Epub 2012 May 15.

Croix JA, Bhatia S, Gaskins HR. Inflammatory cues modulate the expression of secretory product genes, Golgi sulfotransferases and sulfomucin production in LS174T cells. Exp Biol Med, 2011, 236 (12): 1402-12. Epub 2011 Nov 18.

Hong PY, Croix JA, Greenberg E, Gaskins HR, Mackie RI. Pyrosequencing-based analysis of the mucosal microbiota in healthy individuals reveals ubiquitous bacterial groups and micro-heterogeneity. PLoS One, 2011, 6 (9): e25042. Epub 2011 Sep 22.

Croix JA, Carbonero F, Nava GM, Russell M, Greenberg E, Gaskins HR. On the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa. PLoS ONE, 2011, 6 (9): e24447. Epub Sep 9.

Nava GM, Ou J, Carbonero F, Croix JA, Greenberg E, and Gaskins HR. Abundance and diversity of mucosa-associated hydrogenotrophic microbes in the healthy human colon. ISME J, 2012, 6 (1): 57-70. Epub Jul 14 (doi: 10.1038/ismej).

Kolossov VL, Spring BQ, Clegg RM, Henry JJ, Sokolowski A, Kenis PJ, Gaskins HR. Development of a high-dynamic range, GFP-based FRET probe sensitive to oxidative microenvironments. Exp Biol Med, 2011, 236 (6):681-91. Epub 2011 May 23.

Lin C, Kolossov VL, Tsvid G, Trump L, Henry JJ, Henderson JL, Rund LA, Kenis PJ, Schook LB, Gaskins HR, Timp G. Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow. Integr Biol, 2011, 3 (3):208-17. Epub 2010 Dec 23.


Recent Meetings & Abstracts

Experimental Biology 2013
April 20-24, 2013, Boston, MA

Colonic Microbiota Distinguish Native Africans from African and European Americans
F Carbonero, GM Nava, J Ou, SJ O'Keefe, HR Gaskins 

Winner of Best Young Scientist Poster Presentation
Abundance and distribution of mucosa-associated hydrogenotrophs in the healthy colon and in inflamed and non-inflamed tissues of IBD patients
F Carbonero, G Nava, J Croix, E Greenberg, HR Gaskins


Digestive Disease Week
May 18-21, 2013, Orlando, FL

AGA Poster Sessions:
J Ou, K Umeakunne, J DeLany, HR Gaskins, K Newton, SJ O'Keefe
Induction of Methanogenesis in High Colon Cancer Risk African Americans
K Umeakunne, J Ou, J DeLany, HR Gaskins, K Newton, SJ O'Keefe


Cell Symposia: Hallmarks of Cancer
October 29-31, 2012, San Francisco, CA