Mucosal Biology


Ongoing Grants


NIH R33 CA08008   HR Gaskins & PJA Kenis (Co-PIs) 10/10 – 09/13

Title: FRET-based Biosensors to Monitor Redox in Cell Cycle Regulation 
This project pursues novel molecular tools–redox-sensitive biosensors–that will enable in depth examination of the role of redox signaling in cellular processes related to cancer development. Ultimately, the tools will enhance understanding of the extent to which cancerous cells have lost the ability to mount changes in redox potential that accompany normal cell growth versus their sensitivity to these changes.

Carle Development Foundation HRKHL 1208525   E Greenberg, M.D., Carle Hospital (PI) 04/12 - 03/14

Title: Role of Microbial Hydrogen Metabolism in Chronic Constipation and Constipation-Predominant Irritable Bowel Syndrome (IBS)
Tests the hypothesis that higher breath methane observed in patients with chronic constipation and constipation-predominant IBS reflects a greater abundance of mucosa-associated methanogenic archaea in the colonic mucosa of these individuals relative to healthy controls and that differential symptoms of chronic constipation and IBS-C will be correlated with differences in the abundance or diversity of colonic microbes.
Role: PI, UIUC subcontract