Integrative Neurobiology

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Publications

  1. Antonson AM, Radlowski EC, Lawson MA, Rytych JL, Johnson RW. 2016. Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation. Brain Behav Immun. pii: S0889-1591(16)30428-7.

  2. Matt SM, Lawson MA, Johnson RW. 2016. Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1β promoter DNA methylation in microglia. Neurobiol Aging. 47:1-9.

  3. Leyshon BJ, Radlowski EC, Mudd AT, Steelman AJ, Johnson RW. 2016. Postnatal Iron Deficiency Alters Brain Development in Piglets. J Nutr. 146(7):1420-7.

  4. Burton MD, Rytych JL, Amin R, Johnson RW. 2016. Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice. Rejuvenation Res. 19(4):286-92.

  5. Ji P, Schachtschneider KM, Schook LB, Walker FR, Johnson RW. 2016. Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets. Brain Behav Immun. 54:243-51.

  6. Pence BD, Gibbons TE, Bhattacharya TK, Mach H, Ossyra JM, Petr G, Martin SA, Wang L, Rubakhin SS, Sweedler JV, McCusker RH, Kelley KW, Rhodes JS, Johnson RW, Woods JA. 2016. Effects of exercise and dietary epigallocatechin gallate and β-alanine on skeletal muscle in aged mice. Appl Physiol Nutr Metab. 41(2):181-90.

  7. Matt SM, Johnson RW. 2016. Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation. Curr Opin Pharmacol. 26:96-101.

  8. Townsend BE, Johnson RW. 2016. Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice. Exp Gerontol. 73:42-8.

  9. Conrad MS, Sutton BP, Larsen R, Van Alstine WG, Johnson RW. 2015. Early postnatal respiratory viral infection induces structural and neurochemical changes in the neonatal piglet brain. Brain Behav Immun. 48:326-35.

  10. Bhattacharya TK, Pence BD, Ossyra JM, Gibbons TE, Perez S, McCusker RH, Kelley KW, Johnson RW, Woods JA, Rhodes JS. 2015. Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice. Physiol Behav. 145:29-37.

  11. Johnson RW. 2015. Feeding the beast: can microglia in the senescent brain be regulated by diet? Brain Behav Immun. 43:1-8.

  12. Conrad MS, Johnson RW. 2015. The domestic piglet: an important model for investigating the neurodevelopmental consequences of early life insults. Annu Rev Anim Biosci. 3:245-64.

  13. Conrad MS, Harasim S, Rhodes JS, Van Alstine WG, Johnson RW. 2015. Early postnatal respiratory viral infection alters hippocampal neurogenesis, cell fate, and neuron morphology in the neonatal piglet. Brain Behav Immun. 44:82-90.

  14. Liu H, Radlowski EC, Conrad MS, Li Y, Dilger RN, Johnson RW. 2014. Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets. J Nutr. 144(12):1903-9.

  15. Conrad MS, Sutton BP, Dilger RN, Johnson RW. 2014. An in vivo three-dimensional magnetic resonance imaging-based averaged brain collection of the neonatal piglet (Sus scrofa). PLoS One. 9(9):e107650.

  16. Townsend BE, Chen YJ, Jeffery EH, Johnson RW. 2014. Dietary broccoli mildly improves neuroinflammation in aged mice but does not reduce lipopolysaccharide-induced sickness behavior. Nutr Res. 34(11):990-9.

  17. Gibbons TE, Pence BD, Petr G, Ossyra JM, Mach HC, Bhattacharya TK, Perez S, Martin SA, McCusker RH, Kelley KW, Rhodes JS, Johnson RW, Woods JA. 2014. Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice. Behav Brain Res. 272:131-40.

  18. Radlowski EC, Conrad MS, Lezmi S, Dilger RN, Sutton B, Larsen R, Johnson RW. 2014. A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants. PLoS One. 9(3):e91951.

  19. Elmore MR, Burton MD, Conrad MS, Rytych JL, Van Alstine WG, Johnson RW. 2014. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. J Neurosci. 34(6):2120-9.

  20. Radlowski EC, Johnson RW. 2013. Perinatal iron deficiency and neurocognitive development. Front Hum Neurosci. 23;7:585.

  21. Burton, M. D., J. L. Rytych, G. G. Freund, and R. W. Johnson.  2013.  Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice. Brain Behav Immun. 30:66-72.

  22. Rytych, J., M. R. P. Elmore, M. D. Burton, M. S. Conrad, S. M. Donovan, R. N. Dilger, and R. W. Johnson.  2012.  Early life iron deficiency impairs spatial cognition in neonatal piglets.  The Journal of nutrition, 142, 2050-2056.

  23. Conrad, M. S., R. N. Dilger, and R. W. Johnson.  2012.  Brain growth in the domestic pig (Sus scrofa) from 2 to 24 weeks of age:  A longitudinal magnetic resonance imaging study.  Developmental neuroscience, 34, 291-298.

  24. Chiu, G., D. Chatterjee, P. Darmody, J. Walsh, D. Meling, R. Johnson, and G. Freund.  2012.  Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase-1.  J. Neurosci. 32:13945-13955.

  25. Jurgens, H. A. and R. W. Johnson.  2012.  Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection.  Brain Behav. Immun. 26:1006-1016.

  26. Elmore, M. R., R. N. Dilger, and R. W. Johnson.  2012.  Direction learning in a spatial T-maze task by neonatal piglets.  Anim. Cognition 15:667-676.

  27. Lynch, M. A. and R. W. Johnson.  2012.  The impact of aging on the brain—risk, resilience and repair.  Brain Behav. Immun. 26:714-716.

  28. Burton, M. D. and R. W. Johnson 2012. Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning.  Brain Behav. Immun.  26:732-738.

  29. Jurgens, H. A., K. Amancherla, and R. W. Johnson.  2012. Influenza infection induces neuroinflammation, alters hippocampal neuron morphology and impairs cognition in adult mice.  J. Neurosci. 32:3958-3968.

  30. Jurgens, H. A. and R. W. Johnson.  2012.  Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation.  Exp. Neurology. 233:40-48.

  31. Conrad, M. S., R. N. Dilger, A. Nickolls, and R. W. Johnson. 2012. Magnetic resonance imaging of the neonatal piglet brain. Pediatric Res. 71:179-184.

  32. Che, T. M., R. W. Johnson, K. W. Kelley, W. G. Van Alstine, K. A. Dawson, C. A. Moran, and J. E. Pettigrew.  2012.  Effects of mannan oligosaccharide on cytokine secretion by porcine alveolar macrophages and serum cytokine concentrations in nursery pigs. J. Anim. Sci. 90:657-668.

  33. Che, T. M., R. W. Johnson, K. W. Kelley, W. G. Van Alstine, K. A. Dawson, C. A. Moran, and J. E. Pettigrew.  2011.  Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus.  J. Anim. Sci. 89:3016-3029.

  34. Burton, M. D., N. L. Sparkman and R. W. Johnson. 2011. Inhibition of interleukin-6 receptor trans signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior.  J. Neuroinflamm. 8:54-67.

  35. Che, T. M., R. W. Johnson, K. W. Kelley, W. G. Van Alstine, K. A. Dawson, C. A. Moran, and J. E. Pettigrew.  2011. Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus.  J. Anim. Sci. 89:2592-2602. 

  36. Buchanan, J. B., N. L. Sparkman, and R. W. Johnson.  2010.  A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus.  J. Neuroinflamm. 7:82.

  37. Jang, S. and R. W. Johnson.  2010.  Can consuming flavonoids restore old microglia to their youthful state?  Nutrition Rev. 68:719-728.

  38. Jang, S., R. N. Dilger, and R. W. Johnson.  2010.  Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice.  J. Nutr. 140:1892-1898.

  39. Dilger, R. N. and R. W. Johnson. 2010.  Behavioral assessment of cognitive function using a translational neonatal piglet model.  Brain Behav. Immun.  24:1156-1165.

  40. Miguel, J. C., J. Chen, W. G. Van Alstine, and R. W. Johnson.  2010.  Expression of inflammatory cytokines and Toll-like receptors in the brain and respiratory tract of pigs infected with porcine reproductive and respiratory syndrome virus.  Vet. Immunol. Immunopath. 135:314-319.

  41. Buchanan, J. B., Sparkman, N.L., and R. W. Johnson.  2010.  Methamphetamine sensitization attenuates the febrile and neuroinflammatory response to a subsequest peripheral immune stimulus.  Brain Behav. Immun. 24:502-511.         

  42. Abraham, J. and R. W. Johnson.  2009.  Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Research 12:445-453.

  43. Richwine, A. F., N. L. Sparkman, R. N. Dilger, J. B. Buchanan, and R.W. Johnson.  2009.  Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide.  Brain Behav. Immun.23:794-802.

  44. Abraham, J. and R. W. Johnson.  2009.  Central inhibition of interleukin-1β ameliorates sickness behavior in aged mice.  Brain Behav. Immun.  23:396-401.

  45. Sparkman, N. L. and R. W. Johnson.  2008.  Neuroinflammation associated with aging sensitizes the brain to the effects of infection and stress. Neuroimmunomodulation 15:323-330.

  46. Richwine, A. F., A. O. Parkin, J. B. Buchanan, J. Chen, J. A. Markham, J. M. Juraska, and R. W. Johnson.  2008.  Architectural changes to CA1 pyramidal neurons in adult and aged mice after peripheral immune stimulation.  Psychoneurendocrinology 33:1369-1377.

  47. Krzyszton, C. P. N. L. Sparkman, R. W. Grant, J. B. Buchanan, S. R. Broussard, J. Woods, and R. W. Johnson 2008. Exacerbated fatigue and motor deficits in interleukin-10 deficient mice after peripheral immune stimulation.  Am. J. Physiol.295:R1109-R1114.

  48. Huey, K. A., G. Fiscus, A. F. Richwine, R. W. Johnson, and B. M. Meador. 2008.  In vivo vitamin E administration attenuates IL-6 and IL-1b responses to an acute inflammatory insult in mouse skeletal and cardiac muscle.  Exp. Physiol. 93:1263-1272.

  49. Dilger, R. N. and R. W. Johnson.  2008.  Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system.  J. Leukocyte Biol. 84:932-939.

  50. Strle, K., R. McCusker, R. W. Johnson, S. Zunich, R. Dantzer, and K. W. Kelley.  2008.  Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1b.  Am. J. Physiol. 294:E709-718.

  51. Rosczyk, H., N. L. Sparkman, and R. W. Johnson. 2008  Neuroinflammation and cognitive function in aged mice following minor surgery.  Exp. Gerontology 43:840-846. 

  52. Buchanan, J. B., N. L. Sparkman, J. Chen, and R. W. Johnson.  2008.  Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice.  Psychoneuroendocrinolgy 33:755-765.

  53. Jang, S. K. W. Kelley, and R. W. Johnson.  2008.  Luteolin reduces interleukin-6 production in microglia by inhibiting c-Jun N-terminal kinase phosphorylation and activation of AP-1.  Proc. Natl. Acad. Sci. 105:7534-7539.

  54. Meador, B., C. Krzyszton, R. W. Johnson, and K. Huey.  2008.  Effects of IL-10 and age on IL-6, IL-1b, and TNFa:  Responses in mouse skeletal and cardiac muscle to an acute inflammatory insult.  J. Appl. Physiol.  104:991-997.  

  55. O'Connor, J.C., R.H. McCusker, K. Strle, R.W. Johnson, R. Dantzer and K.W. Kelley. 2008. Regulation of IGF-I function by proinflammatory cytokines: At the interface of immunology and endocrinology. Cellular Immunology 252:91-110.

  56. Godbout, J. P., M. Moreau, J. Lestage, J. Chen, N. L. Sparkman, N. Castanon, K. W. Kelley, R. Dantzer, and R. W. Johnson.  2008.  Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.  Neuropsychopharmacology 33:2341-2351.

  57. Huang, Y., C. J. Henry, R. Dantzer, R. W. Johnson, and J. P. Godbout.  2008.  Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide.  Neurobiol. Aging 29:1744-1753.

  58. Chen, J., J. B. Buchanan, N. L. Sparkman, J. P. Godbout, G. G. Freund, and R. W. Johnson.  2008.  Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system.  Brain Behav. Immun.22:301-311. 

  59. Dantzer, R., J. C. O’Connor, G. G. Freund, R. W. Johnson, and K. W. Kelley.  2008.  From inflammation to sickness and depression:  When the immune system subjugates the brain.  Nature Rev. Neurosci. 9:46-56.

  60. Buchanan, J. B. and R. W. Johnson.  2007.  Regulation of food intake by inflammatory cytokines in the brain.  J. Neuroendocrinol. 86:183-190.

  61. Strle, K., R. H. McCusker, L. Tran, A. King, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley.  2007.  Novel activity of an anti-inflammatory cytokine:  IL-10 prevents TNFa-induced resistance to IGF-I in myoblasts.  J. Neuroimmunol. 188:48-55.  

  62. Escobar, J., W. G. Van Alstine, D. H. Baker, and R. W. Johnson.  2007.  Behavior of pigs with viral and bacterial pneumonia.  J. Appl. Anim. Behav. Sci. 105:42-50.

  63. Abraham, J., S. Jang, J. P. Godbout, J. Chen, K. W. Kelley, R. Dantzer, and R. W. Johnson.  2006.  Aged mice are more sensitive to behavioral deficits induced by centrally administered HIV-1 gp120. Neurobiol. Aging 29:614-621.

  64. Sutherland, M. A., S. R. Niekamp, R. W. Johnson, W. G. Van Alstine, and J. L. Salak-Johnson.  2007.  Heat and social rank impact behavior and physiology of PRRS-virus-infected pigs.  Physiol. Behav. 90:73-81.

  65. Gaykema, R. P. A., M. K. Balachandran, J. P. Godbout, R. W. Johnson, and L. E. Goehler.  2007.  Enhanced neuronal activation in central autonomic network nuclei in aged mice following acute peripheral immune challenge.  Autonom. Neurosci.131:137-142.

  66. McCusker, R. H., K McCrea, S. Zunich, R. Dantzer, S. R. Broussard, R. W. Johnson, and K. W. Kelley.  2006.  Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons.  J. Neuroimmunol. 179:186-190.

  67. Sparkman, N. L., J. B. Buchanan, J. R. R. Heyen, J. Chen, J. L. Beverly, and R. W. Johnson.  2006.  Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers.  J. Neurosci. 26:10709-10716.

  68. Sterle, K., S. R. Broussard, R. H. McCusker, W. H. Shen, J. M. LeCleir, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley.  2006.  JNK mediates TNFa suppression of differentiation in myoblasts.  Endocrinology 147:4363-4373. 

  69. Selvaraj, V., D. Bunick, R. W. Johnson, L. Liu, and P. S. Cooke.  2005.  Gene expression profiling of 17b-estradiol and genistein effects on mouse thymus.  Toxicological Sci.  87:97-112.

  70. Escobar, J., T. L. Toepfer-Berg, J. Chen, W. G. Van Alstine, J. M. Campbell and R. W. Johnson.  2006.  Supplementing drinking water with Solutein did not mitigate acute morbidity effects of PRRSV in nursery pigs.  J. Anim. Sci.  84:2101-2109.

  71. Godbout, J. P., B. M. Berg, C. Krzyszton, and R. W. Johnson.  2005.  a-Tocopherol attenuates NFkB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior.  J. Neuroimmunol. 169:97-105.

  72. O’Connor, J.C, Satpathy, A, Hartman, M.E., Horvath, E.M., Kelley, K.W., Dantzer, R., Johnson, R.W., Freund, G.G.  2005.  IL-1b-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J. Immunol.  174:4991-4997.

  73. Richwine, A. F., J. P. Godbout, B. M. Berg, J. Chen, J. Escobar, D. K. Millard, and R. W. Johnson.  2005.  Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo interleukin-6 production.  Brain Behav. Immun.  19:512-520.

  74. Godbout, J. P., J. Chen, J. Abraham, A. F. Richwine, B. M. Berg, K. W. Kelley, and R. W. Johnson.  2005.  Exaggerated neuroinflammation and sickness in aged mice following activation of the peripheral innate immune system.  FASEB J.  19:1329-1331.

  75. Berg, B. M., J. P. Godbout, J. Chen, K. W. Kelley, and R. W. Johnson.  2005.  a-Tochopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice.  J. Nutr.  135:1157-1163.

  76. Hyun, Y., M. Ellis, S. E. Curtis, and R. W. Johnson.  2005.  Environmental temperature, space allowance, and regrouping:  Additive effects of multiple concurrent stressors in growing pigs.  J. Swine Health Prod. 13:131-138.

  77. Johnson, R. W. and J. Escobar.  2005.  Immune system: nutrition effects.  In:  Encyclopedia of An. Sci., Eds. Wilson Pond and Alan Bell, Marcel Dekker, Inc. pg 541-543.

  78. Escobar, J., W. G. Van Alstine, D. H. Baker, and R. W. Johnson.  2004.  Decreased protein accretion in pigs with viral and bacterial pneumonia is associated with increased myostatin expression in muscle.  J. Nutr.  134:3047-3053.

  79. Chen, J. and R. W. Johnson.  2004.  Dehydroepiandrosterone-sulfate did not mitigate sickness behavior in mice.  Physiol. Behav.  82:713-719.

  80. Strle, K., S. R. Broussard, R. H. McCusker, W. H. Shen, R. W. Johnson, G. G. Freund, R. Dantzer and K. W. Kelley.  2004.  Proinflammatory cytokine impairment of IGF-I-induced protein synthesis in skeletal muscle myoblasts requires ceramide.  Endocrinology 145:4592-4602.

  81. Toepfer-Berg, T. L., J. Escobar, W. G. Van Alstine, D. H. Baker, J. L. Salak-Johnson, and R. W. Johnson.  2004.  Vitamin E supplementation does not mitigate the acute morbidity effects of porcine reproductive and respiratory syndrome virus in nursery pigs. J. Anim. Sci. 82:1942-1951.

  82. Shen, W. H., J. H. Zhou, S. R. Broussard, R. W. Johnson, R. Dantzer, and K. W. Kelley.  2004. Tumor necrosis factor a inhibits insulin-like growth factor-I-Induced hematopoietic cell survival and proliferation. Endocrinology 145:3101-3105.

  83. Shen, W. H., S. T. Jackson, S. R. Broussard, R. H. McCusker, K. Strle, G. G. Freund, R. W. Johnson, R. Dantzer and K. W. Kelley. 2004. Interleukin-1b suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. J. Immunol. 172:7272-7281.

  84. Broussard, S. R., R. H. McCusker, J. E. Novakofski, K. Strle, W. H. Shen, R. W. Johnson, R. Dantzer, and K. W. Kelley.  2004.  Interleukin-1b impairs IGF-I-induced differentiation and downstream activation signals of the IGF-I receptor in myoblasts. J. Immunol. 172:7713-7720.

  85. Godbout, J. P., B. M. Berg, K. W. Kelley, and R. W. Johnson.  2004.  a-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.  J. Neuroimmunol. 149:101-109.

  86. Berg, B. M. J. P. Godbout, K. W. Kelley, and R. W. Johnson, 2004.  a-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice.  Brain Behav. Immun. 18:149-157.

  87. Godbout, J. P. and R. W. Johnson.  2004.  Interleukin-6 in the aging brain. J. Neuroimmunol. 147:141-144.

  88. Broussard, S. R., R. H. McCusker, J. E. Novakofski, K. Strle, W. H. Shen, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley. 2003.  Cytokine-hormone interactions: tumor necrosis factor{alpha} impairs biologic activity and downstream activation signals of the IGF-I receptor in myoblasts.  Endocrinology 144:2988-2996.

  89. Kelley, K. W., R. M. Bluthé, R. Dantzer, J. H. Zhou, W. H. Shen, R. W. Johnson, and S. R. Broussard.  2003.  Cytokine-induced sickness behavior.  Brain Behav. Immun. 117:S112-S118.

  90. Johnson, R. W.  2002.  The concept of sickness behavior: A brief chronological account of four key discoveries.  Vet. Immunol. Immunopath. 87:443-450.

  91. Finck, B. N. and R. W. Johnson.  2002.  Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-a.  Am. J. Physiol. 282:R1429-R1435.

  92. Escobar, J., W. G. Van Alstine, D. H. Baker, and R. W. Johnson.  2002.  Growth performance and whole-body composition of pigs experimentally infected with Mycoplasma hyopneumoniae.  J. Anim. Sci. 80:384-391.

  93. Strle, K., J. H. Zhou, S. R. Broussard, H. D. Venters, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley.  2002.  Interleukin-10 promotes survival of microglia without activating AKT.  J. Neuroimmunol. 122:9-19.

  94. Strle, K., J. H. Zhou, S. R. Broussard, R. W. Johnson, G. G. Freund, R. Dantzer and K. W. Kelley.  2001.  IL-10 in the brain.  Crit. Rev. Immunol. 21:427-449

  95. Ye, S. M. and R. W. Johnson.   2001.  An age-related decline in interleukin (IL)-10 may contribute to the increased expression of IL-6 in brain of aged mice.  Neuroimmunomodulation 9:183-192.

  96. Johnson, R. W. and B. N. Finck.  2001.  Tumor necrosis factor a and leptin:  two players in animals’ metabolic and immunologic responses to infection.  J. Anim. Sci. 79(E. Suppl.):E118-E127.

  97. Broussard, S., J. H. Zhou, H. D. Venters, R. M. Bluthé, R. W. Johnson, R. Dantzer, and K. W. Kelley. 2001.  At the interface of environment-immune interactions: cytokines and growth factor receptors.  J. Anim. Sci. 79:E268-E284.

  98. Zhou, J. H., S. R. Broussard, K. Strle, G. G. Freund, R. W. Johnson, R. Dantzer and K. W. Kelley. 2001.  IL-10 inhibits apoptosis of promyeloid cells by activating insulin-receptor substrate-2 and phosphatidylinositol 3’-kinase.  J. Immunol. 167:4436-4442.

  99. Venters, H. D., S. R. Broussard, J. H. Zhou, R. M. Bluthe, G. G. Freund, R. W. Johnson, R. Dantzer, and K. W. Kelley.  2001.  Tumor necrosis factor a and insulin-like growth factor-I in the brain: Is the whole greater than the sum of its parts?  J. Neuroimmunol. 119:151-165.

  100. Ye, S. M. and R. W. Johnson.  2001.  Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor k B.  J. Neuroimmunol. 117:87-96.

  101. Finck, B. N. and R. W. Johnson.  2000.  Regulation of leptin production by the lipostatic cytokine, tumor necrosis factor-a.  Microscopy Res. Tech. 50:209-215.

  102. Heyen, J. R. R., S. M. Ye, B. N. Finck, and R. W. Johnson.  2000.  Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kB.  Mol. Brain Res. 77:138-147.

  103. Finck, B. N. and R. W. Johnson.  2000.  Tumor necrosis factor (TNF)-a induces leptin secretion through the p55 TNF receptor. Am. J. Physiol. 278:R537-R543.

  104. Yao, J.-H., S.-M. Ye, W. Burgess, J. F. Zachary, K. W. Kelley, and R. W. Johnson.  1999.  Mice deficient in interleukin-1b converting enzyme resist anorexia induced by central lipopolysaccharide.  Am. J. Physiol. 277:R1435-R1443.

  105. Baker, D. H. and R. W. Johnson.  1999.  Disease stress, cytokines and amino acid needs of pigs.  Pig News Info. 20:123-124.

  106. Nelson, K. P., N. L. Marks, J. R. R. Heyen, and R. W. Johnson.  1999.  Behavior of adult and aged mice before and after central injection of interleukin-1b. Physiol. Behav. 66:673-679.

  107. Finck, B. N. and R. W. Johnson.  1999.  Lipopolysaccharide in the brain increases circulating leptin levels.  NeuroReport 10:153:156.

  108. Dantzer, R., G. Gheusi, R. W. Johnson, and K. W. Kelley.  1999.  Central administration of insulin-like growth factor-I inhibits lipopolysaccharide-induced sickness behavior in mice.  NeuroReport 10:289-292.

  109. Ye, S. and R. W. Johnson.  1999.  Increased interleukin-6 expression by microglia from brain of aged mice.  J. Neuroimmunol. 93:139-148.

  110. Webel, D. M., R. W. Johnson, and D. H. Baker.  1998.  Lipopolysaccharide-induced reductions in body weight gain and feed intake do not reduce the efficiency of arginine utilization for whole-body protein accretion in chicks.  Poultry Sci. 77:1893-1898.

  111. Hyun, Y., M. Ellis, and R. W. Johnson.  1998.  Effects of feeder type, space allowance and mixing on the growth performance and feed intake pattern of growing pigs.  J. Anim. Sci. 76:2771-2778.

  112. Webel, D. M., R. W. Johnson, and D. H. Baker.  1998.  Lipopolysaccharide-induced reductions in food intake do not decrease the efficiency of lysine and threonine utilization for protein accretion in chickens.  J. Nutr. 128:1760-1766.

  113. Webel, D. M., D. C. Mahan, R. W. Johnson, and D. H. Baker.  1998.  Pretreatment of young pigs with vitamin E attenuates the elevation in plasma interleukin-6 and cortisol caused by a challenge dose of lipopolysaccharide.  J. Nutr. 128:1657-1660.

  114. R. L Matteri, Klir, J. J., B. N. Finck, and R. W. Johnson.  1998.  Neuroendocrine-immune interactions in the neonate.  Dom. Anim. Endocrinol. 15:397-407.

  115. Johnson, R. W.  1998.  Immune and endocrine regulation of food intake in sick animals.  Dom. Anim. Endocrinol. 15:309-318.

  116. Burgess, W., G. Gheusi, J. Yao, R. W. Johnson, R. Dantzer, and K. W. Kelley.  1998.  Interleukin-1b converting enzyme deficient mice resist central but not systemic endotoxin-induced aphagia.  Am. J. Physiol. 274:R1829-R1833.

  117. Finck, B. N., K. W. Kelley, R. Dantzer, and R. W. Johnson.  1998.  In vivo and in vitro evidence for the involvement of tumor necrosis factor-a in the induction of leptin by lipopolysaccharide.  Endocrinology 139:2278-2283.

  118. Hyun, Y., M. Ellis, G. Riskowski, and R. W. Johnson.  1998.  Growth performance of pigs subjected to multiple concurrent environmental stressors.  J. Anim. Sci. 76:721-727.

  119. Yao, J. and R. W. Johnson.  1997.  Induction of interleukin-1b converting enzyme (ICE) in murine microglia by lipopolysaccharide.  Mol. Brain Res. 51:170-178.

  120. Finck, B. N. and R. W. Johnson.  1997.  Anorexia, weight loss, and increased plasma interleukin-6 induced by chronic intracerebroventricular infusion of interleukin-1b in the rat.  Brain Res. 761:333-337.

  121. Segreti, J., G. Gheusi, R. Dantzer, K. W. Kelley, and R. W. Johnson.  1997.  Defect in interleukin-1b secretion prevents sickness behavior in C3H/HeJ mice.  Physiol. Behav. 61:873-878.

  122. Webel, D. M., B. N. Finck, D. H. Baker, and R. W. Johnson.  1997.  Time course of elevated plasma cytokines, cortisol and urea-nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J. Anim. Sci. 75:1514-1520.

  123. Warren, E. J., B. N. Finck, S. Arkins, K. W. Kelley, R. W. Scamurra, M. P. Murtaugh, and R. W. Johnson.  1997.  Coincidental changes in behavior and plasma cortisol in unrestrained pigs following intracerebroventricular injection of tumor necrosis factor-a.  Endocrinology 138:2365-2371.

  124. Johnson, R. W., G. Gheusi, S. Segreti, R. Dantzer, and K. W. Kelley.  1997.  C3H/HeJ mice are refractory to lipopolysaccharide in the brain.  Brain Res. 752:219-226.

  125. Johnson, R. W.  1997.  Inhibition of growth by pro-inflammatory cytokines:  an integrated view.  J. Anim. Sci.  75:1244-1255.

  126. Finck, B. N., R. Dantzer, K. W. Kelley, J. Woods, and R. W. Johnson.  1997.  Central lipopolysaccharide elevates plasma interleukin-6 concentration by an a-adrenoreceptor-mediated mechanism.  Am. J. Physiol.  272:R1880-R1887.

  127. Johnson, R. W., S. Arkins, R. Dantzer, and K. W. Kelley.  1997.  Hormones, lymphohemopoietic cytokines and the neuroimmune axis.  Comp. Biochem. Physiol. 116:183-201.

  128. Propes, M. J. and R. W. Johnson.  1997.  Role of corticosterone in the behavioral effects of central interleukin-1b.  Physiol. Behav. 61:7-13.

  129. Johnson, R. W., M. J. Propes, and Y. Shavit.  1996.  Corticosterone modulates the behavioral and metabolic effects of lipopolysaccharide.  Am. J. Physiol. 270:R192-R198.

  130. Kelley, K. W., R. W. Johnson, and R. Dantzer.  1994.  Immunology discovers physiology.  Vet. Immunol. Immunopathol. 43:157-165.

  131. Johnson, R. W., E. von Borell, L. L. Anderson, L. D. Kojic, and J. E. Cunnick.  1994.  Intracerebroventricular injection of corticotropin-releasing hormone in the pig:  acute effects on behavior, adrenocorticotropin secretion, and immune suppression. Endocrinology 135:642-648.

  132. Johnson, R. W. and E. von Borell.  1994.  Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin.  J. Anim. Sci. 72:309-314.

  133. Johnson, R. W., S. E. Curtis, R. Dantzer, J. M. Bahr, and K. W. Kelley.  1993.  Sickness behavior in birds caused by peripheral or central injection of endotoxin.  Physiol. Behav. 53:343-348.

  134. Johnson, R. W., S. E. Curtis, R. Dantzer and K. W. Kelley.  1993.  Central and peripheral prostaglandins are involved in sickness behavior in the chicken.  Physiol. Behav. 53:127-131.

  135. Johnson, R. W., S. E. Curtis, and R. D. Shanks.  1991.  Effects on chick performance of ammonia and heat stressors in various combination-sequences.  Poultry Sci. 70:1132-1137.