Nutrition, Health, and Neuroscience Laboratory




  1. Mudd AT, Dilger RN. Early-life nutrition and neurodevelopment: Use of the piglet as a translational model. Advances in Nutrition. January 2017, 8, 92-104. doi: 10.3945/an.116.013243.
  2. Fleming SA, Dilger RN. Young pigs exhibit differential exploratory behavior during novelty preference tasks in response to age, sex, and delay. Behavioural Brain Research. March 2017, 321, 50-60. doi: 10.1016/j.bbr.2016.12.027
  3. Mudd AT, Alexander LS, Johnson SK, Getty CM, Malysheva OV, Caudill MA, Dilger RN. Perinatal dietary choline deficiency in sows influences concentrations of choline metabolites, fatty acids, and amino acids in milk throughout lactation. J. Nutr. Oct 2016. doi:10.3945/jn.116.238832
  4. Jacob RM, Mudd AT, Alexander LS, Lai CS, and Dilger RN. Comparison of brain development in sow-reared and artificially reared piglets. Front. Pediatr. July 2016. 4:95. doi:10.3389/fped.2016.00095
  5. Mudd AT, Waworuntu RV, Berg BM, Dilger RN. Dietary alpha-lipoic acid alters piglet neurodevelopment. Front. Pediatri. 2016. 4:44. doi: 10.3389/fped.2016.00044. 
  6. Berding K, Wang M, Monaco MH, Alexander LS, Mudd AT, Chichlowski M, Waworuntu R, Berg B, Miller MJ, Dilger RN, Donovan SM. Prebiotics and bioactive milk fractions affect gut development, microbiota, and neurotransmitter expression in piglets. J of Pediatr Gastroenterol Nutr. 2016. doi:10.1097/MPG.0000000000001200
  7. Mudd AT, Alexander LS, Berding K, Waworuntu RV, Berg BM, Donovan SM and Dilger RN . Dietary prebiotics, milk fat globule membrane and lactoferrin affects structural neurodevelopment in the young piglet. Front. Pediatr2016. 4:4. doi: 10.3389/fped.2016.00004
  8. Getty CM, Almeida FN, Baratta AA, Dilger RN. Plasma metabolomics indicates metabolic perturbations in low birth weight piglets supplemented with arginine. J Anim Sci. 2015 Dec;93(12):5754-63. doi: 10.2527/jas.2015-9293
  9. Panasevich MR, Allen JM, Wallig MA, Woods JA, Dilger RN. Moderately Fermentable Potato Fiber Attenuates Signs and Inflammation Associated with Experimental Colitis in Mice. J Nutr. 2015 Dec;145(12):2781-8. doi:10.3945/jn.115.218578.
  10. Mudd AT, Getty CM, Sutton BP, Dilger RN. Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. Nutr Neurosci. 2015 Jun 5. doi: 10.1179/1476830515Y.0000000031
  11. Rochell SJ, Alexander LS, Rocha GC, Van Alstine WG, Boyd RD, Pettigrew JE, Dilger RN. Effects of dietary soybean meal concentration on growth and immune response of pigs infected with porcine reproductive and respiratory syndrome virus. J Anim Sci. 2015 Jun;93(6):2987-97. doi: 10.2527/jas.2014-8462.
  12. Panasevich MR, Kerr KR, Serao MC, de Godoy MR, Guérin-Deremaux L, Lynch GL, Wils D, Dowd SE, Fahey GC, Swanson KS, Dilger RN. Evaluation of soluble corn fiber on chemical composition and nitrogen-corrected true metabolizable energy and its effects on in vitro fermentation and in vivo responses in dogs. J Anim Sci. 2015 May;93(5):2191-200. doi: 10.2527/jas.2014-8425.
  13. Rendeiro C, Masnik AM, Mun JG, Du K, Clark D, Dilger RN, Dilger AC, Rhodes JS. Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet. Sci Rep. 2015 Apr 20;5:9589. doi: 10.1038/srep09589.
  14. Getty CM, Dilger RN. Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet. PLoS One. 2015 Jul 21;10(7):e0133500. doi: 10.1371/journal.pone.0133500.
  15. Liu H, Radlowski EC, Conrad MS, Li Y, Dilger RN, Johnson RW. Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets. J Nutr. 2014 Dec;144(12):1903-9. doi:10.3945/jn.114.199828.
  16. Panasevich MR, Kerr KR, Dilger RN, Fahey GC, Guérin-Deremaux L, Lynch GL, Wils D, Suchodolski JS, Steiner JM, Dowd SE, Swanson KS. Modulation of the faecal microbiome of healthy adult dogs by inclusion of potato fibre in the diet. Br J Nutr. 2014 Nov 24:1-9. [Epub ahead of print].
  17. Almeida JA, Ponnuraj NP, Lee JJ, Utterback P, Gaskins HR, Dilger RN, Pettigrew JE. Effects of dietary clays on performance and intestinal mucus barrier of broiler chicks challenged with Salmonella enterica serovar Typhimurium and on goblet cell function in vitro. Poult Sci. 2014 Apr;93(4):839-47. doi:10.3382/ps.2013-03587.
  18. Conrad MS, Sutton BP, Dilger RN, Johnson RW. An in vivo three-dimensional magnetic resonance imaging-based averaged brain collection of the neonatal piglet (Sus scrofa). PLoS One. 2014 Sep 25;9(9):e107650. doi: 10.1371/journal.pone.0107650.
  19. Radlowski EC, Conrad MS, Lezmi S, Dilger RN, Sutton B, Larsen R, Johnson RW. A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants. PLoS One. 2014 Mar 17;9(3):e91951. doi:10.1371/journal.pone.0091951.
  20. Panasevich MR, Rossoni Serao MC, de Godoy MR, Swanson KS, Guérin-Deremaux L, Lynch GL, Wils D, Fahey GC Jr, Dilger RN. Potato fiber as a dietary fiber source in dog foods. J Anim Sci. 2013 Nov;91(11):5344-52. doi: 10.2527/jas.2013-6842.
  21. Johnson RW, Donovan SM, Dilger RN. Reply to Maitre et al. J Nutr. 2013 Apr;143(4):549.
  22. Wils-Plotz EL, Dilger RN. Combined dietary effects of supplemental threonine and purified fiber on growth performance and intestinal health of young chicks. Poult Sci. 2013 Mar;92(3):726-34. doi: 10.3382/ps.2012-02664.
  23. Dilger RN, Bryant-Angeloni K, Payne RL, Lemme A, Parsons CM. Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks. Poult Sci. 2013 Jan;92(1):171-7. doi: 10.3382/ps.2012-02425.
  24. Faber TA, Dilger RN, Hopkins AC, Price NP, Fahey GC Jr. Effects of oligosaccharides in a soybean meal-based diet on fermentative and immune responses in broiler chicks challenged with Eimeria acervulina. Poult Sci. 2012 Dec;91(12):3132-40. doi: 10.3382/ps.2012-02364.
  25. Rytych JL, Elmore MR, Burton MD, Conrad MS, Donovan SM, Dilger RN, Johnson RW. Early life iron deficiency impairs spatial cognition in neonatal piglets. J Nutr. 2012 Nov;142(11):2050-6. doi: 10.3945/jn.112.165522.
  26. Elmore MR, Dilger RN, Johnson RW. Place and direction learning in a spatial T-maze task by neonatal piglets. Anim Cogn. 2012 Jul;15(4):667-76. doi:10.1007/s10071-012-0495-9.
  27. Faber TA, Dilger RN, Hopkins AC, Price NP, Fahey GC Jr. The effects of a galactoglucomannan oligosaccharide-arabinoxylan (GGMO-AX) complex in broiler chicks challenged with Eimeria acervulina. Poult Sci. 2012 May;91(5):1089-96.doi: 10.3382/ps.2011-01993.
  28. Conrad MS, Dilger RN, Nickolls A, Johnson RW. Magnetic resonance imaging of the neonatal piglet brain. Pediatr Res. 2012 Feb;71(2):179-84. doi:10.1038/pr.2011.21.
  29. Conrad MS, Dilger RN, Johnson RW. Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: a longitudinal MRI study. Dev Neurosci. 2012;34(4):291-8. doi: 10.1159/000339311.
  30. Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG. Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Obesity (Silver Spring). 2011 Aug;19(8):1586-94. doi: 10.1038/oby.2011.73.
  31. Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res. 2011 Jul;31(7):563-71. doi:10.1016/j.nutres.2011.06.004.
  32. Dilger RN, Johnson RW. Behavioral assessment of cognitive function using a translational neonatal piglet model. Brain Behav Immun. 2010 Oct;24(7):1156-65. doi: 10.1016/j.bbi.2010.05.008.
  33. Jang S, Dilger RN, Johnson RW. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr. 2010 Oct;140(10):1892-8. doi: 10.3945/jn.110.123273.
  34. Sherry CL, Kim SS, Dilger RN, Bauer LL, Moon ML, Tapping RI, Fahey GC Jr, Tappenden KA, Freund GG. Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization. Brain Behav Immun. 2010 May;24(4):631-40. doi:10.1016/j.bbi.2010.01.015.
  35. Richwine AF, Sparkman NL, Dilger RN, Buchanan JB, Johnson RW. Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide. Brain Behav Immun. 2009 Aug;23(6):794-802. doi: 10.1016/j.bbi.2009.02.020.
  36. Sands JS, Ragland D, Dilger RN, Adeola O. Responses of pigs to Aspergillus niger phytase supplementation of low-protein or high-phytin diets. J Anim Sci. 2009 Aug;87(8):2581-9. doi: 10.2527/jas.2009-1772.
  37. Bryant KI, Dilger RN, Parsons CM, Baker DH. Dietary L-homoserine spares threonine in chicks. J Nutr. 2009 Jul;139(7):1298-302. doi:10.3945/jn.109.104372.
  38. Dilger RN, Johnson RW. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol. 2008 Oct;84(4):932-9. doi: 10.1189/jlb.0208108.
  39. Dilger RN, Baker DH. Excess dietary L-cysteine causes lethal metabolicacidosis in chicks. J Nutr. 2008 Sep;138(9):1628-33.
  40. Dilger RN, Baker DH. Cyst(e)ine imbalance and its effect on methionine precursor utilization in chicks. J Anim Sci. 2008 Aug;86(8):1832-40. doi:10.2527/jas.2007-0712.
  41. Dilger RN, Kobler C, Weckbecker C, Hoehler D, Baker DH. 2-keto-4-(methylthio)butyric acid (keto analog of methionine) is a safe and efficacious precursor of L-methionine in chicks. J Nutr. 2007 Aug;137(8):1868-73.
  42. Dilger RN, Baker DH. Oral N-acetyl-L-cysteine is a safe and effective precursor of cysteine. J Anim Sci. 2007 Jul;85(7):1712-8. Epub 2007 Mar 19.
  43. Dilger RN, Toue S, Kimura T, Sakai R, Baker DH. Excess dietary L-cysteine, but not L-cystine, is lethal for chicks but not for rats or pigs. J Nutr. 2007 Feb;137(2):331-8.
  44. Dilger RN, Martinez Amezcua C, Pillai PB, Emmert JL, Parsons CM, Baker DH. Effect of reciprocating dietary lysine fluctuations on chick growth and carcass yield. Poult Sci. 2006 Jul;85(7):1226-31.
  45. Jendza JA, Dilger RN, Adedokun SA, Sands JS, Adeola O. Escherichia coli phytase improves growth performance of starter, grower, and finisher pigs fed phosphorus-deficient diets. J Anim Sci. 2005 Aug;83(8):1882-9.
  46. Dilger RN, Onyango EM, Sands JS, Adeola O. Evaluation of microbial phytase in broiler diets. Poult Sci. 2004 Jun;83(6):962-70.
  47. Norberg SE, Dilger RN, Dong H, Harmon BG, Adeola O, Latour MA. Utilization of energy and amino acids of spray-dried egg, plasma protein, and soybean meal by ducks. Poult Sci. 2004 Jun;83(6):939-45.
  48. Dilger RN, Sands JS, Ragland D, Adeola O. Digestibility of nitrogen and amino acids in soybean meal with added soyhulls. J Anim Sci. 2004 Mar;82(3):715-24.